Alexander Shulgin Research Institute

Publications

Publications

ASRI scientists publish their work in the world’s leading research and medical journals.
  1. A matter of mass. KF Foley, NV Cozzi, PF Daley. J. Appl. Lab. Med., June (2023) DOI: 10.1093jalm-jfad037
  2. Exploratory investigation of a patient-informed low dose psilocybin pulse regimen in the suppression of cluster headache: Results from a randomized, double-blind, placebo-controlled trial. EAD Schindler, RA Sewell, CH Gottschalk, C Luddy, LT Flynn, Y Zhu, H Lindsey, BP Pittman, NV Cozzi, DC D’Souza. Headache, (2022) DOI: 10.1111/head.14420
  3. Exploratory study of the dose-related safety, tolerability, andefficacy of dimethyltryptamine (DMT) in healthy volunteers and major depressive disorder. DC D’Souza, SA Syed, LT Flynn, H Safi-Aghdam, NV Cozzi, M Ranganathan. Neuropsychopharmacology, (2022). DOI: 10.1038/s41386-022-01344-y
  4. Psilocybin: crystal structure solutions enable phase analysis of prior art and recently patented examples. AM Sherwood, RB Kargbo, KW Kaylo, NV Cozzi, P Meisenheimer, JA Kaduk.  Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 78, 36-55 (2022). DOI: 10.1107/S2053229621013164
  5. N,N-Dimethyltryptamine attenuates spreading depolarization and restrains neurodegeneration by sigma-1 receptor activation in the ischemic rat brain. Í Szabó, VÉ Varga, S Dvorácskó, AE Farkas, T Körmöczi, R Berkecz, S. Kecskés, Á Menyhárt, R Frank, D Hantosi, NV Cozzi, E Frecska, C Tömböly, IA Krizbai, F Bari, E Farkas. Neuropharmacology, 192, 108612 (2021). DOI: 10.1016/j.neuropharm.2021.108612
  6. Exploratory controlled study of the migraine-suppressing effects of psilocybin. EAD Schindler, RA Sewell, CH Gottschalk, C Luddy, LT Flynn, H Lindsey, BP Pittman, NV Cozzi, DC D’Souza. Neurotherapeutics, 18, 534-543 (2021). DOI:10.1007/s13311-020-00962-y
  7. Synthesis and characterization of high-purity DMT hemifumarate for human clinical trials. NV Cozzi, PF Daley. Drug Test. Anal., 12, 1483-1493 (2020). DOI:10.1002/dta.2889
  8. Direct phosphorylation of psilocin enables optimized cGMP kilogram-scale manufacture of psilocybin. R Kargbo, A Sherwood, A Walker, NV Cozzi, RE Dagger, J Sable, K O’Hern, K Kaylo, T Patterson, G Tarpley, P Meisenheimer. ACS Omega, 5, 16959-16966 (2020). DOI:10.1021/acsomega.0c02387
  9. para-Trifluoromethyl-methcathinone is an allosteric modulator of the serotonin transporter. M Niello, D Cintulova, E Hellsberg, K Jäntsch, M Holy, LH Ayatollahi, NV Cozzi, M Freissmuth, W Sandtner, GF Ecker, MD Mihovilovic, HH Sitte. Neuropharmacology, 161, 107615-107626 (2019). DOI:10.1016/j.neuropharm.2019.04.021
  10. High dose psilocybin is associated with positive subjective effects. CR Nicholas, KM Henriquez, MC Gassman, KM Cooper, D Muller, S Hetzel, RT Brown, NV Cozzi, C Thomas, PR Hutson. J. Psychopharmacol., 32, 770-778 (2018). DOI:10.1177/0269881118780713
  11. Receptor binding profiles and behavioral pharmacology of ring-substituted N,N-diallyltryptamine analogs. LM Klein, NV Cozzi, PF Daley, SD Brandt, AL Halberstadt. Neuropharmacology, 142, 231-239 (2018). DOI:10.1016/j.neuropharm.2018.02.028
  12. Pharmacokinetics of ecalating doses of oral psilocybin in healthy adults. RT Brown, CR Nicholas, NV Cozzi, MC Gassman, KM Cooper, D Muller, CD Thomas, SJ Hetzel, KM Henriquez, AS Ribaudo, PR Hutson. Clin. Pharmacokinet., 56, 1543-1554 (2017). DOI:10.1007/s40262-017-0540-6
  13. Atypical dopamine efflux caused by 3,4-methylenedioxypyrovalerone (MDPV) via the human dopamine transporter. A Shekar, JI Aguilar, G Galli, NV Cozzi, SD Brandt, AE Ruoho, MH Baumann, HJG Matthies, A Galli. J. Chem. Neuroanat., 83-84, 69-74 (2017). DOI:10.1016/j.jchemneu.2017.01.004
  14. Combined simulation and mutation studies to elucidate selectivity of unsubstituted amphetamine-like cathinones at the dopamine transporter. A Seddik, DP Geerke, T Stockner, M Holy, O Kudlacek, NV Cozzi, AE Ruoho, HH Sitte, GF Ecker. Mol. Inform., 36, 5-6, (2017). DOI:10.1002/minf.201600094
  15. Receptor binding profiles and quantitative structure-affinity relationships of some 5-substituted-N,N-diallyltryptamines. NV Cozzi, PF Daley. Bioorg. Med. Chem. Lett., 26, 959-964 (2016). DOI:10.1016/j.bmcl.2015.12.053
  16. Reinforcing and neurochemical effects of the “bath salts” constituents 3,4-methylenedioxypyrovalerone (MDPV) and 3,4-methylenedioxy-N-methylcathinone (methylone) in male rats. CW Schindler, EB Thorndike, S Goldberg, KR Lehner, NV Cozzi, SD Brandt, MH Baumann. Psychopharmacology, 233, 1981-1990 (2016). DOI:10.1007/s00213-015-4057-0
  17. Quantitative structure-activity relationship analysis of the pharmacology of para-substituted methcathinone analogues. JS Bonano, ML Banks, R Kolanos, F Sakloth, M Barnier, RA Glennon, NV Cozzi, JS Partilla, MH Baumann, SS Negus. Brit. J. Pharmacol., 172, 2433-2444 (2015). DOI:10.1111/bph.13030
  18. Noncompetitive inhibition of indolethylamine-N-methyltransferase by N,N-dimethyltryptamine and N,N-dimethylaminopropyltryptamine. UB Chu, S Vorperian, K Satyshur, K Eickstaedt, NV Cozzi, AR Hajipour, AE Ruoho. Biochemistry, 53, 2956-2965 (2014). DOI:10.1021/bi500175p
  19. Radiotracers for cardiac sympathetic innervation: transport kinetics and binding affinities for the human norepinephrine transporter. DM Raffel, W Chen, Y-W Jung, K-S Jang, G Gua, NV Cozzi. Nucl. Med. Biol., 40, 331-337 (2013). DOI:10.1016/j.nucmedbio.2012.11.014
  20. Pharmacological examination of trifluoromethyl ring-substituted methcathinone analogs. NV Cozzi, SD Brandt, PF Daley, JS Partilla, RB Rothman, A Tulzer, HH Sitte, MH Baumann. Eur. J. Pharmacol., 699, 180-187 (2013). DOI:10.1016/j.ejphar.2012.11.008
  21. Powerful cocaine-like actions of 3,4-methylenedioxypyrovalerone (MDPV), a principal constituent of psychoactive “bath salts” products. MH Baumann, JS Partilla, KR Lehner, EB Thorndike, AF Hoffman, M Holy, RB Rothman, SR Goldberg, CR Lupica, HH Sitte, SD Brandt, SR Tella, NV Cozzi, CW Schindler. Neuropsychopharmacology, 38, 552-562 (2013). DOI:10.1038/npp.2012.204
  22. Analytical characterization of three trifluoromethyl-substituted methcathinone isomers. SD Brandt, PF Daley, NV Cozzi. Drug Test. Anal., 4, 525-529 (2012). DOI:10.1002/dta.382
  23. Synthesis and characterization of 5-methoxy-2-methyl-N,N-dialkylated tryptamines. SD Brandt, R Tearavarich, N Dempster, NV Cozzi, PF Daley. Drug Test. Anal., 4, 24-32 (2012). DOI:10.1002/dta.398
  24. The designer methcathinone analogs, mephedrone and methylone, are substrates for monoamine transporters in brain tissue. MH Baumann, MA Ayestas, JS Partilla, JL Sink, AT Shulgin, PF Daley, SD Brandt, RB Rothman, AE Ruoho, NV Cozzi. Neuropsychopharmacology, 37, 1192-1203 (2012). DOI:10.1038/npp.2011.304
  25. Microwave-accelerated preparation and analytical characterization of 5-ethoxy-N,N-dialkyl-[α,α,β,β-H4]- and [α,α,β,β-D4]-tryptamines. R Tearavarich, V Hahnvajanawong, N Dempster, PF Daley, NV Cozzi, SD Brandt. Drug Test. Anal., 3, 597‑608 (2011). DOI:10.1002/dta.223
  26. Clinal geographic variation in mescaline concentration among Texas populations of Lophophora williamsii (Cactaceae). D Hulsey, MA Kalam, PF Daley, N Fowler, M Terry. J. Bot. Res. Inst. Texas 5, 677-683 (2011)
  27. New mescaline concentrations from 14 taxa-cultivars of Echinopsis spp. (Cactaceae)(‘San Pedro’) and their relevance to shamanic practice. O Ogunbodede, D McCombs, K Trout, PF Daley,  M Terry. J. Ethnopharmacology, 131, 356-362 (2010). DOI:10.1016/j.jep.2010.07.021
  28. Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transporter and the vesicle monoamine transporter. NV Cozzi, A Gopalakrishnan, LL Anderson, JT Feih, AT Shulgin, PF Daley, AE Ruoho. J. Neural Transm., 116, 1591-1599 (2009). DOI:10.1007/s00702-009-0308-8
  29. The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator. D Fontanilla, M Johannessen, AR Hajipour, NV Cozzi, MB Jackson, AE Ruoho. Science, 323, 934-937 (2009). DOI:10.1126/science.1166127
  30. Psychoactive N,N-dialkyltryptamines modulate serotonin transport by at least two mechanisms. NV Cozzi, AT Shulgin, PF Daley, A Gopalakrishnan, LL Anderson, JT Feih, AE Ruoho. Soc. Neurosci. Abs., 34, 536.17 (2008)
  31. Microwave-accelerated synthesis of psychoactive deuterated N,N-dialkylated-[α,α,β,β-D4]-tryptamines. SD Brandt, SS Tirunarayanapuram, S Freeman, N Dempster, SA Barker, PF Daley, NV Cozzi, CPB Martins. J. Label. Compd. Radiopharm., 51, 423-429 (2008). DOI:10.1002/jlcr.1557
  32. Synthesis and biological evaluation of 2-(4-fluorophenoxy)-2-phenyl-ethyl piperazines as serotonin-selective reuptake inhibitors with a potentially improved adverse reaction profile. JM Dorsey, MG Miranda, NV Cozzi, KG Pinney. Bioorg. Med. Chem., 12, 1483-1491 (2004). DOI:10.1016/j.bmc.2003.12.021
  33. Methcathinone is a substrate for the serotonin uptake transporter. NV Cozzi, KF Foley. Pharmacol. Toxicol., 93, 219-225 (2003). DOI:10.1046/j.1600-0773.2003.pto930504.x
  34. Novel aminopropiophenones as potential antidepressants. KF Foley, NV Cozzi. Drug Dev. Res., 60, 252-260 (2003). DOI:10.1002/ddr.10297
  35. Stereospecific inhibition of monoamine uptake transporters by meta-hydroxyephedrine isomers. KF Foley, ME Van Dort, MK Sievert, AE Ruoho, NV Cozzi. J. Neural Transm., 109, 1229-1240 (2002). DOI:10.1007/s00702-002-0695-6
  36. Inhibition of transport function and desipramine binding at the human noradrenaline transporter by N-ethylmaleimide and protection by substrate analogs. KF Foley, NV Cozzi. Naunyn-Schmiedeberg’s Arch. Pharmacol., 365, 457-461 (2002). DOI:10.1007/s00210-002-0532-3
  37. Rapid and efficient method for suspending cells for neurotransmitter uptake assays. NV Cozzi, KF Foley. Biotechniques, 32, 486-492 (2002). DOI:10.2144/02323bm03
  38. Inhibition of plasma membrane monoamine transporters by β-ketoamphetamines. NV Cozzi, MK Sievert, AT Shulgin, P Jacob III, AE Ruoho. Eur. J. Pharmacol., 381, 63-69 (1999). DOI:10.1016/S0014-2999(99)00538-5
  39. Methcathinone and 2-methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one (methylone) selectively inhibit plasma membrane catecholamine reuptake transporters. NV Cozzi, MK Sievert, AT Shulgin, P Jacob III, AE Ruoho. Soc. Neurosci. Abs., 24, 341.8 (1998)
  40. Methcathinone (MCAT) and 2-methylamino-1-(3,4-methylenedioxy-phenyl)propan-1-one (MDMCAT) inhibit [3H]serotonin uptake into human platelets. NV Cozzi, AT Shulgin, AE Ruoho. Amer. Chem. Soc. Div. Med. Chem. Abs., 215, 152 (1998)
  41. Conformationally restricted tetrahydro-1-benzoxepin analogs of hallucinogenic phenethylamines. AP Monte, D Marona-Lewicka, NV Cozzi, DL Nelson, DE Nichols.  Med. Chem. Res. 5, 651-663 (1995). DOI:10.1002/chin.199621182.
  42. Synthesis and pharmacological examination of benzofuran, indan, and tetralin analogs of 3,4‑(methylenedioxy)amphetamine. AP Monte, D Marona-Lewika, NV Cozzi, DE Nichols.  J. Med. Chem., 36, 3700-3706 (1993). DOI:10.1021/jm00075a027.
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