Alexander Shulgin Research Institute

Basic Science

Basic Science

Psychedelic drug design involves

 

  • de novo chemical synthesis
  • natural product isolation
  • pharmacological testing of new and existing substances

Design and synthesis of novel compounds

  • Structure-activity relationships
  • In vitro and in vivo pharmacology
  • Pattern-guided, fragment-based, and artificial intelligence-augmented drug design

Innovative chemical syntheses

  • Isotope labeling
  • Green chemistry
  • Streamlined chemical processes

Isolation of natural products

Advanced analytics

  • GC/MS, LC/MS/MS
  • Thermogravimetric analysis, differential scanning calorimetry
  • NMR, IR, Raman spectroscopy
  • X-ray diffraction analysis

Neuropsychopharmacology

  • Receptor pharmacology, neurochemistry
  • Neural circuitry
  • Brain imaging
  • Correlation of in vitro and animal data with human experiential effects
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